Conjunctival Nevi

Immunohistochemical studies of atypical conjunctival melanocytic nevi.

OBJECTIVE To evaluate with immunohistochemical methods 5 atypical melanocytic conjunctival lesions. METHODS This was a retrospective clinicoimmunopathologic study. Routine histochemical staining was performed with multiparametric immunohistochemical analysis with monoclonal antibodies immunoreacted on paraffin sections to identify the following cell antigens: S-100, MART-1, HMB-45, CD45, CD68...

Immunohistochemical studies of conjunctival nevi and melanomas.

OBJECTIVE To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations. DESIGN Retrospective immunohistopathologic study. METHODS Paraffin-embedded tissue sections from 20 conjunctival nevi and 15 invasive melanomas were immunoreacted with antibodies against cellular antigens S-100 protein, MART-1, HMB-45, CD-45, and Ki...

BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.

Purpose To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all ...

Blue Conjunctival Nevi: A Benign Tumor of Atypical Localization, Conjunctival Blue Nevus: Benign Tumor Formed at an Atypical Location

Conjunctival nevi: clinical features and natural course in 410 consecutive patients.

OBJECTIVES To describe the clinical features of a conjunctival nevus and to evaluate the lesion for changes in color and size over time. DESIGN Retrospective, observational, noncomparative case series. PARTICIPANTS Four hundred ten consecutive patients with conjunctival nevi. MAIN OUTCOME MEASURES The 2 main outcome measures were changes in tumor color and size. RESULTS Of the 410 patie...